Gian Paolo Fadini Selected Research

Insulin Resistance

2/2019	Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66Shc.
1/2019	Cross-talk of healthy and impaired human tissues for dissection of disease pathogenesis.
1/2018	Interplay between gut microbiota and p66Shc affects obesity-associated insulin resistance.
1/2017	Reduced circulating stem cells associate with excess fasting and post-load NEFA exposure in healthy adults with normal glucose tolerance.
12/2015	Circulating Stem Cells Associate With Adiposity and Future Metabolic Deterioration in Healthy Subjects.
10/2015	p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans.
7/2015	High Temporal Resolution Detection of Patient-Specific Glucose Uptake from Human ex Vivo Adipose Tissue On-Chip.
12/2014	Endothelial progenitor cells are reduced in acromegalic patients and can be restored by treatment with somatostatin analogs.
5/2011	Impaired hemodynamic response to meal intake in insulin-resistant subjects: an impedance cardiography approach.
4/2010	Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms.

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Gian Paolo Fadini Research Topics

Disease

62	Type 2 Diabetes Mellitus (MODY) 03/2024 - 05/2010
24	Body Weight (Weight, Body) 03/2024 - 01/2014
13	Insulin Resistance 02/2019 - 08/2007
12	Hypoglycemia (Reactive Hypoglycemia) 10/2022 - 06/2009
12	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 09/2013
11	Heart Failure 10/2023 - 09/2015
11	Inflammation (Inflammations) 01/2023 - 03/2008
8	Atherosclerosis 11/2020 - 09/2006
7	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 10/2022 - 01/2017
7	Hyperglycemia 07/2022 - 03/2006
7	COVID-19 06/2022 - 10/2020
7	Ischemia 01/2022 - 03/2010
7	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2015 - 04/2010
6	Obesity 01/2023 - 10/2015
6	Diabetes Complications 12/2020 - 06/2009
5	Weight Gain 12/2022 - 01/2014
5	Myocardial Infarction 01/2022 - 11/2016
5	Stroke (Strokes) 01/2022 - 07/2010
5	Infections 01/2022 - 01/2016
5	Wounds and Injuries (Trauma) 01/2020 - 09/2010
5	Vascular Calcification 02/2016 - 08/2007
4	Albuminuria 03/2024 - 10/2014
4	Weight Loss (Weight Reduction) 10/2020 - 12/2013
4	Hypoxia (Hypoxemia) 11/2019 - 09/2010
4	Peripheral Arterial Disease 08/2018 - 03/2010
4	Ulcer 08/2018 - 03/2010
3	Diabetes Mellitus 01/2024 - 04/2017
3	Neoplasms (Cancer) 12/2023 - 01/2012
3	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 10/2023 - 01/2017
3	Coma (Comas) 02/2021 - 06/2009
3	Vascular Diseases (Vascular Disease) 08/2015 - 03/2008
2	Pain (Aches) 01/2024 - 04/2017
2	Pneumonia (Pneumonitis) 12/2023 - 10/2020
2	Reproductive Tract Infections 10/2023 - 01/2018
2	Chronic Renal Insufficiency 10/2023 - 10/2017
2	Necrosis 08/2023 - 10/2014
2	Glucose Intolerance 01/2023 - 05/2010
2	Fatty Liver 12/2022 - 01/2020
2	Fournier Gangrene 11/2021 - 01/2019
2	Ketosis 11/2021 - 01/2020
2	Hypertension (High Blood Pressure) 01/2020 - 12/2014
2	Overweight 01/2020 - 06/2015
2	Chronic Limb-Threatening Ischemia 04/2017 - 02/2006

Drug/Important Bio-Agent (IBA)

49	Glucose (Dextrose)FDA LinkGeneric 03/2024 - 06/2009
27	Insulin (Novolin)FDA Link 02/2024 - 08/2007
13	Dipeptidyl-Peptidase IV InhibitorsIBA 09/2021 - 07/2013
12	Glucagon-Like Peptide-1 Receptor AgonistsIBA 11/2021 - 01/2018
11	dapagliflozinIBA 03/2024 - 01/2017
11	Sodium-Glucose Transporter 2 InhibitorsIBA 12/2022 - 01/2017
11	erucylphosphocholineIBA 01/2018 - 05/2005
9	SodiumIBA 11/2021 - 01/2017
7	omega-Chloroacetophenone (Mace)IBA 12/2022 - 10/2015
7	Oxygen (Dioxygen)IBA 03/2021 - 01/2005
7	Liraglutide FDA Link 03/2021 - 12/2013
6	LipidsIBA 03/2024 - 09/2011
6	insulin degludecIBA 04/2023 - 12/2019
5	Proteins (Proteins, Gene)FDA Link 12/2022 - 04/2010
5	EnzymesIBA 02/2019 - 08/2007
5	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2018 - 02/2006
5	Hypoglycemic Agents (Hypoglycemics)IBA 01/2018 - 01/2011
4	Blood Glucose (Blood Sugar)IBA 02/2024 - 07/2019
4	Insulin Glargine (Lantus)FDA Link 04/2023 - 03/2021
4	InsulinsIBA 04/2023 - 12/2019
4	Glucagon-Like Peptide 1 (GLP 1)IBA 12/2022 - 07/2011
4	SirtuinsIBA 01/2022 - 01/2010
4	Biomarkers (Surrogate Marker)IBA 12/2020 - 09/2006
4	HDL CholesterolIBA 08/2018 - 08/2014
3	semaglutideIBA 03/2024 - 01/2020
3	IDegLiraIBA 02/2024 - 03/2021
3	Sodium-Glucose Transport ProteinsIBA 10/2023 - 04/2021
3	CytokinesIBA 01/2022 - 07/2011
3	Glucagon-Like Peptide-1 ReceptorIBA 11/2021 - 01/2014
3	LDL CholesterolIBA 01/2021 - 04/2008
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2021 - 01/2010
3	CholesterolIBA 11/2020 - 01/2017
3	dulaglutideIBA 01/2020 - 01/2020
3	Metformin (Glucophage)FDA LinkGeneric 08/2018 - 09/2015
3	Sirtuin 1IBA 07/2015 - 04/2010
2	GlucocorticoidsIBA 12/2023 - 10/2020
2	Phosphotransferases (Kinase)IBA 12/2023 - 03/2008
2	Hemoglobins (Hemoglobin)IBA 01/2023 - 01/2019
2	ProcalcitoninIBA 06/2022 - 02/2021
2	pro-brain natriuretic peptide (1-76)IBA 01/2022 - 10/2017
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 01/2012
2	Streptozocin (Streptozotocin)FDA Link 01/2022 - 09/2010
2	empagliflozinIBA 04/2021 - 11/2016
2	lixisenatideIBA 03/2021 - 11/2016
2	C-Reactive ProteinIBA 02/2021 - 07/2010
2	plerixafor FDA Link 01/2020 - 01/2018
2	Exenatide (Byetta)FDA Link 01/2020 - 01/2019
2	Gliclazide (Diamicron)IBA 08/2018 - 01/2018
2	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 01/2018 - 10/2014
2	LinagliptinIBA 10/2017 - 02/2016

Therapy/Procedure

24	Therapeutics 12/2023 - 07/2006
8	Surgical Amputation (Amputations) 01/2024 - 03/2010
7	Glycemic Control 10/2022 - 01/2014
3	Hematopoietic Stem Cell Mobilization 01/2020 - 01/2013
2	Injections 03/2024 - 01/2020
2	Critical Care (Surgical Intensive Care) 06/2022 - 01/2022
2	Transplantation 01/2019 - 01/2018